Microscale chemistry allows concepts to be taught with less expense, less waste and concomitant environmental impact and less hazard in terms of safety. See a titration involving a strong acid and a strong base, and a weak acid and a strong base. These microscale activities have complete descriptions of how to prepare and carry out the experiment. Traditionally the titration involves counting the drops of acid added to the 24-well plate and the counting the number of drops of base needed to reach end-point. In carrying out these experiments maintaining consistent drop size is important.

If you have access to an electronic balance, the entire 24-well plate can be placed on the balance pan before and after adding the acid. Likewise the mass can be determined again after adding drops of NaOH to reach endpoint. Knowing the mass of acid and the mass of base used in the titration will provide a more accurate picture of both the amount of acid and base. Another strategy is to weigh the Beral pipets before and after.